What is anthranilic acid used for?

Industrially, anthranilic acid is an intermediate in the production of azo dyes and saccharin. It and its esters are used in preparing perfumes to mimic jasmine and orange, pharmaceuticals (loop diuretics, such as furosemide) and UV-absorber as well as corrosion inhibitors for metals and mold inhibitors in soy sauce.

Which drug is anthranilic acid derivatives?

Furosemide, an anthranilic acid derivative, is a rapid acting, highly efficacious diuretic Rankin (2002).

Is N anthranilic acid?

Fenamic acid is an aminobenzoic acid that is the N-phenyl derivative of anthranilic acid. It acts as a parent skeleton for the synthesis of several non-steroidal anti-inflammatory drugs. It has a role as a membrane transport modulator. It is a secondary amino compound and an aminobenzoic acid.

What is an anthranilic acid derivative?

Background: Anthranilic acid derivatives are important pharmacophores in drug discovery. Several of them are currently being used, such as mefenamic acid and meclofenamates, possess analgesic, anti-inflammatory and antipyretic activities.

Is Ibuprofen a propionic acid derivative?

Ibuprofen was the first member of Propionic acid derivatives introduced in 1969. It is a popular domestic and over the counter analgesic and antipyretic for adults and children.

How do you make anthranilic acid?

Dissolve 7.5 g NaOH in 40 ml water and cool in ice bath to about 0°C temperature and then add 2.1 ml Br2 solution to it. To this solution add 6 g phthalamide and 20 ml 10% KOH solution, then heat the solution for 5-10 minutes till phthalamide dissolves.

Which of the following is N aryl anthranilic acid derivative?

N-aryl anthranilic acid and its derivatives (3a-f) have been synthesized via Ullmann condensation of o-chloro benzoic acid with various substituted anilines (2a-f) in the presence of cupric oxide and anhydrous potassium carbonate.

Which function group is present in anthranilic acid?

Anthranilic acid is an aromatic acid with the formula C6H4(NH2)(CO2H) and has a sweetish taste. The molecule consists of a benzene ring, ortho-substituted with a carboxylic acid and an amine. As a result of containing both acidic and basic functional groups, the compound is amphoteric.

What is the density of anthranilic acid?

1.4 g/cm³ Anthranilic acid/Density

When anthranilic acid is treated with nitrous acid gives?

Treatment of anthranilic acid with nitrous acid gives an intermediate, A, that contains a diazonium ion and a carboxylate group. When this intermediate is heated in the pres- ence of furan, a tricyclic compound is formed.

Which hazard does not apply to methanol?

Possible hazardous reactions:None under normal processing. Conditions to avoid:Excess heat, Incompatible Materials, flames, or sparks. Incompatible materials: Oxidizing agents, reducing agents, alkali metals, acids, sodium, potassium, metals as powders, acid chlorides, acid anhydrides, powdered magnesium, and aluminum.

What are the hazards of salicylic acid?

  • Eye: Causes severe eye irritation.
  • Skin: Contact with skin causes irritation and possible burns, especially if the skin is wet or moist.
  • Ingestion: Causes gastrointestinal irritation with nausea, vomiting and diarrhea.
  • Inhalation: Causes irritation of the mucous membrane and upper respiratory tract.

Is salicylic acid a phenol?

Salicylic acid contains a phenol group, and phenols are known to be irritating. Aspirin can be made by reacting salicylic acid with acetic acid in the presence of an acid catalyst. The phenol group on the salicylic acid forms an ester with the carboxyl group on the acetic acid.

What is the common name of O aminobenzoic acid?

anthranilic acid 2-Aminobenzoic acid, also known as anthranilic acid or O-aminobenzoate, belongs to the class of organic compounds known as aminobenzoic acids.

How is Benzyne generated from anthranilic acid?

Benzyne is generated by the dehalogenation of 2-bromofluorobenzene by magnesium. Anthranilic acid can be converted to 2-diazoniobenzene-1-carboxylate by diazotization and neutralization. Although explosive, this zwitterionic species is a convenient and inexpensive precursor to benzyne.

What happen when anthranilic acid undergoes decarboxylation?

Benzyne formation – Diazotization-decarboxylation of Anthranilic acid (2-aminobenzoic acid) Diazotization of anthranilic acid produces a diazonium salt which can lose nitrogen and carbon dioxide to produce benzyne. The benzyne intermediate also appears in the aromatic substitution reactions.

What is the structure of anthranilic acid?

C7H7NO2 Anthranilic acid/Formula

Which of the following moiety is essential for the activity of anthranilic acid derivatives types of nsaids?

The NH moiety of anthranilic acid is essential for the activity as the replacement of NH function with O, CH2, S, SO2, N-CH3, or NCOCH3 functionalities significantly reduced the activity.

Is N anthranilic and derivatives?

General information. The NSAID mefenamic acid is an anthranilic acid derivative.

Which of the following diuretic is anthranilic acid derivative?

Furosemide [Furosemide: a new diuretic derivative of anthranilic acid]

What is the molecular weight of anthranilic acid?

137.14 g/mol Anthranilic acid/Molar mass

Which of the following anti-inflammatory drug is an phenylpropionic acid derivative?

NSAIDs come in different chemical groupings; oxicams (meloxicam, piroxicam, tenoxicam) and phenylpropionic (arylpropionic) acid derivatives (e.g. fenbufen, ibuprofen, naproxen, tiaprofenic acid, mefenamic acid).

Is naproxen an acid?

Naproxen is a propionic acid derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities. Naproxen inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes.

Is 1 ibuprofen a day bad?

Linder says the current recommendations for ibuprofen are to “limit daily use to no more than 30 days,” with a daily maximum of 3,200 milligrams per day. If you go past this limit, the negative effects will “begin to outweigh the desired benefits of decreased discomfort and pain,” he warns.

How do you make Phthalimides?

Phthalimide can be prepared by heating phthalic anhydride with alcoholic ammonia giving 95–97% yield. Alternatively, it may be prepared by treating the anhydride with ammonium carbonate or urea. It can also be produced by ammoxidation of o-xylene.

How do you make phthalic anhydride?

Phthalic anhydride is presently obtained by catalytic oxidation of ortho–xylene or naphthalene. When separating the phthalic anhydride from production by products such as o–xylene in water, or maleic anhydride, a series of “switch condensers” is required. Phthalic anhydride can also be prepared from phthalic acid.

What is the melting point of phthalic anhydride?

267.8°F (131°C) Phthalic anhydride/Melting point

Which drug is an indole derivative?

Delavirdine: Anti-HIV drug. Apaziquone as anticancer, Oxypertine as antipsychotic and Arbidol as antiviral. Oxypertine (Figure 10) is an antipsychotic and antidepressant used in the treatment of schizophrenia. Chemically, it is an indole derivative similarly to molindone and a member of the phenylpiperazine class [48].

Which of the drugs are aniline derivatives?

The history of acetaminophen dates back to the late 1800s, when the antipyretic activity of aniline derivatives was discovered and several congeners, including acetaminophen, were synthesized. For some reason, two other aniline derivatives, acetanilid and phenacetin, became popular, and acetaminophen was not used.

What is the correct Iupac nomenclature of mefenamic acid?

Mefenamic acid is a nonsteroidal antiinflammatory drug (NSAID) used largely for acute treatment of pain. 2Biologic Description.

SVG Image
IUPAC Condensed Ph(2,3-diMe)-2Abz-OH
Sequence X
HELM PEPTIDE1{[Cc1cccc(c1C)Nc2ccccc2C(=O)O]}$$$$
IUPAC N-(2,3-dimethylphenyl)-2-aminobenzoic acid

What is the Iupac name of Ortho aminobenzoic acid?

Anthranilic acid

PubChem CID 227
Structure Find Similar Structures
Chemical Safety Laboratory Chemical Safety Summary (LCSS) Datasheet
Molecular Formula C7H7NO2
Synonyms anthranilic acid 2-aminobenzoic acid 118-92-3 o-aminobenzoic acid o-Carboxyaniline More

What is the melting point of salicylic acid?

317.5°F (158.6°C) Salicylic acid/Melting point

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