What is aminophylline used for?

Aminophylline is used to prevent and treat wheezing, shortness of breath, and difficulty breathing caused by asthma, chronic bronchitis, emphysema, and other lung diseases. It relaxes and opens air passages in the lungs, making it easier to breathe.

What kind of drug is aminophylline?

Aminophylline belongs to a group of medicines known as bronchodilators. Bronchodilators are medicines that relax the muscles in the bronchial tubes (air passages) of the lungs. They relieve cough, wheezing, shortness of breath, and troubled breathing by increasing the flow of air through the bronchial tubes.

What are aminophylline side effects?

Aminophylline side effects fast or irregular heartbeats; a seizure; high blood sugar–increased thirst, increased urination, dry mouth, fruity breath odor; or. low potassium level–leg cramps, constipation, irregular heartbeats, fluttering in your chest, numbness or tingling, muscle weakness or limp feeling.

Why Aminophylline is given slowly?

Intravenous Aminophylline must be administered very slowly to prevent dangerous central nervous system and cardiovascular side-effects due to direct stimulating effect of Aminophylline.

What is the antidote for aminophylline?

Intravenous aminophylline: morphine as antidote to poisoning.

Does aminophylline lower BP?

When both active treatments were combined, the effect on total electromechanical systole, corrected for heart rate, was potentiated (mean decrease -23.3 msec; range -19.1 to -33.1). Neither aminophylline nor the combination affected heart rate or blood pressure, suggesting no increase in myocardial oxygen consumption.

Does aminophylline increase blood pressure?

Aminophylline increased mean arterial pressure 12 +/- 2%, LV systolic pressure 8 +/- 1%, LV dP/dt 20 +/- 2%, velocity of myocardial fiber shortening 13 +/- 2% and heart rate 5 +/- 2%, and reduced LV end-diastolic diameter 2 +/- 0.5%.

Does aminophylline increase heart rate?

Aminophylline competitively antagonizes the cardiac actions of adenosine at the cell surface receptors. Thus, it increases heart rate and contractility.

Does aminophylline raise blood sugar?

Aminophylline stimulates insulin secretion in patients with type 2 diabetes mellitus. Metabolism.

Is Aminophylline still available?

aminophylline has been discontinued by the manufacturer and is no longer available.

How quickly does aminophylline work?

Regular use of this medication does not cause it to lose its effect or make you more dependent on it. This medication may be used alone or with an inhaled bronchodilator. How fast does this medication work? This medication works within 30 minutes.

How do you administer aminophylline?

Aminophylline Injection is administered by slow intravenous injection or diluted and administered by intravenous infusion. The solution contains no bacteriostat or antimicrobial agent and is intended for use only as a single-dose injection. When smaller doses are required the unused portion should be discarded.

How do you mix aminophylline?

Add 500mg to 500mL or 250mg to 250mL of a compatible infusion fluid (1mg/mL). Administer using a rate controlled infusion pump. Aminophylline infusions should be continued for at least 24 hours with review by medical staff at agreed intervals, and may be continued for a further 24-48 hours.

Is Aminophylline a diuretic?

Background: Aminophylline, an established bronchodilator, is also purported to be an effective diuretic and anti-inflammatory agent.

What are the contraindications of aminophylline?

Aminophylline contraindications include patients with hypersensitivity to theophylline, ethylenediamine, or any component of the drug formulation. Contraindications

  • Cardiac disease.
  • Renal impairment.
  • Hepatic dysfunction due to any cause.
  • Hypo/hyperthyroidism.
  • Epilepsy.
  • Active peptic ulcer disease[19]

What is normal theophylline level?

Therapeutic serum levels of theophylline are between 10 to 20 mcg/ml. Most adults achieve these concentrations with daily slow-release oral theophylline preparations, 200-400 mg (approximately 10 mg/Kg) twice a day.

What should you check before giving theophylline?

Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: stomach/intestinal ulcer, seizures, thyroid disease, heart problems (such as heart failure, irregular heartbeat), liver disease, high blood pressure.

How does aminophylline work in the body?

Aminophylline is a bronchodilator. Aminophylline works in several ways: it relaxes muscles in your lungs and chest to allow more air in, decreases the sensitivity of your lungs to allergens and other substances that cause inflammation, and increases the contractions of your diaphragm to draw more air into the lungs.

What is the generic name for aminophylline?

Theophylline is available under the following different brand names: Theo 24, Theochron, Elixophyllin, aminophylline, and Uniphyl.

When should I take aminophylline levels?

With oral use Plasma-theophylline concentration is measured 5 days after starting oral treatment and at least 3 days after any dose adjustment. A blood sample should usually be taken 4–6 hours after an oral dose of a modified-release preparation (sampling times may vary—consult local guidelines).

Can aminophylline cause hypotension?

Both compounds produced a dose-dependent hypotension. Aminophylline frequently caused bradycardia in intact dogs and positive chrono- and inotropic effects in isolated atria.

Can aminophylline cause arrhythmia?

We conclude that orally-administered aminophylline has both arrhythmogenic and chronotropic effects, but does not change the grade of arrhythmia.

What happens when aminophylline is exposed to air?

Upon exposure to air Aminophylline gradually loses ethylenediamine and absorbs carbon dioxide with the liberation of free theophylline. Even in the absence of light, Aminophylline is gradually degraded on exposure to a humid atmosphere, the decomposition being faster at higher temperatures. Definition.

Can you be allergic to aminophylline?

Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

How do you calculate aminophylline?

Converting IV aminophylline to ORAL aminophylline: Calculate the total amount administered in 24 hours by multiplying the hourly infusion rate by 24. This calculation assumes infusion concentration prepared is 1mg/ml.

Is Aminophylline an anti inflammatory?

Aminophylline has bronchodilatory and a variety of other anti-inflammatory properties due to its ability to inhibit phosphodiesterase.

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