What is aminoglutethimide used for?

Aminoglutethimide is an anti-hormone medication. Aminoglutethimide interferes with the body’s production of certain hormones. Aminoglutethimide is used in the treatment of conditions which cause the body to make too much of certain hormones (Cushing’s syndrome).

Is aminoglutethimide a steroid?

Aminoglutethimide is an adrenal steroid inhibitor, which means it interferes with the hormones produced by the adrenal gland.

What enzyme is inhibited by aminoglutethimide?

Aminoglutethimide inhibits the enzymatic conversion of cholesterol to pregnenolone, thereby decreasing adrenal glucocorticoids, mineralocorticoids, estrogens, and androgens.

What are the side effects of metyrapone?

Nausea, upset stomach, headache, dizziness, or drowsiness may occur. If any of these effects persist or worsen, tell your doctor promptly. Remember that your doctor has prescribed this medication because the benefit to you is greater than the risk of side effects.

Which conditions is Aminoglutethimide cytadren used to treat?

Cytadren (aminoglutethimide) is indicated for the suppression of adrenal function in selected patients with Cushing’s syndrome.

What is the mode of action of Aminoglutethimide?

Aminoglutethimide inhibits the enzymatic conversion of cholesterol to D5-pregnenolone, resulting in a decrease in the production of adrenal glucocorticoids, mineralocorticoids, estrogens, and androgens.

What drug class is Aminoglutethimide?


Clinical data
Drug class Aromatase inhibitor; Antiestrogen; Steroidogenesis inhibitor; Antiglucocorticoid
ATC code L02BG01 (WHO)
Pharmacokinetic data
Bioavailability Rapid, complete

Why does Aminoglutethimide cause adrenal insufficiency?

Aminoglutethimide inhibits the enzymatic conversion of cholesterol to pregnenolone, thereby decreasing adrenal glucocorticoids, mineralocorticoids, estrogens, and androgens.

How is mitotane administered?

Recommended Dose The recommended initial dose of LYSODREN is 2 g to 6 g orally, in three or four divided doses per day. Increase doses incrementally to achieve a blood concentration of 14 to 20 mg/L, or as tolerated. LYSODREN is a cytotoxic drug. Follow applicable special handling and disposal procedures.

What is the mechanism of action of ketoconazole?

Ketoconazole is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections. It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increasing membrane fluidity and preventing growth of the fungus.

What is anastrozole 1mg?

Anastrozole is used to treat breast cancer in women after menopause. Some breast cancers are made to grow faster by a natural hormone called estrogen. Anastrozole decreases the amount of estrogen the body makes and helps to slow or reverse the growth of these breast cancers.

What is diethylstilbestrol used for?

What is DES? Diethylstilbestrol (DES) is a synthetic form of the female hormone estrogen. It was prescribed to pregnant women between 1940 and 1971 to prevent miscarriage, premature labor, and related complications of pregnancy (1).

Does ketoconazole make your skin peel?

Tell your doctor if you have the following symptoms while using the ketoconazole 2% shampoo: hair discoloration, abnormal hair texture, removal of the curl from permanently waved hair, hair loss, itching, burning sensation of the skin, or blistering, peeling, or redness of the skin.

Is Metopirone a steroid?

Metyrapone is used in the diagnosis of certain problems of the adrenal glands. These glands are located near the kidneys. The adrenal glands produce a steroid chemical called cortisol (hydrocortisone) that helps the body respond to stress or illness.

How does ketoconazole treat Cushing’s?

Ketoconazole is effective for long term control of hypercortisolism of either pituitary or adrenal origin. Its effect appears to be mediated by inhibition of adrenal 11 beta-hydroxylase and 17,20-lyase, and it, in some unknown way, prevents the expected rise in ACTH secretion in patients with Cushing’s disease.

What is the use of Testolactone?

Testolactone ( INN , USAN ) (brand name Teslac) is a non-selective, irreversible, steroidal aromatase inhibitor which is used as an antineoplastic drug to treat advanced-stage breast cancer.

What does methimazole do to the body?

Methimazole can lower blood cells that help your body fight infections and help your blood to clot. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often.

What is Fludrocort?

Collapse Section. Fludrocortisone, a corticosteroid, is used to help control the amount of sodium and fluids in your body. It is used to treat Addison’s disease and syndromes where excessive amounts of sodium are lost in the urine. It works by decreasing the amount of sodium that is lost (excreted) in your urine.

What are corticosteroids?

Commonly referred to as steroids, corticosteroids are a type of anti-inflammatory drug. They are typically used to treat rheumatologic diseases, like rheumatoid arthritis, lupus or vasculitis (inflammation of the blood vessels). Specific corticosteroids include the medications cortisone and prednisone.

How do you pronounce Aminoglutethimide?

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How is exemestane given?

Exemestane is a pill, taken by mouth. You should take exemestane at about the same time each day. Take with food. If you miss a dose, do not take a double dose the next day.

What type of diuretic is eplerenone?

Synopsis: Eplerenone, a potassium-sparing diuretic similar to spironolactone, selectively blocks aldosterone to lower blood pressure. However, its safety profile is improved over spironolactone because of reduced progesterone and androgen-receptor effects.

Are glucocorticoids?

Glucocorticoids are powerful medicines that fight inflammation and work with your immune system to treat wide range of health problems. Your body actually makes its own glucocorticoids. These hormones have many jobs, such as controlling how your cells use sugar and fat and curbing inflammation.

How long can you take mitotane?

The ESE-ENSAT guidelines and ESMO guidelines suggest continued use of adjuvant mitotane for at least 2 years, but not longer than 5 years [10,17].

How long does mitotane stay in your system?

Following discontinuation of LYSODREN, the plasma terminal half-life has ranged from 18 to 159 days. In most patients blood levels become undetectable after 6 to 9 weeks.

Is mitotane a chemotherapy?

The most commonly recommended chemotherapy drug for adrenal cancer is mitotane. In addition to destroying adrenal cancer cells, mitotane suppresses the adrenal gland’s production of hormones.

What does ketoconazole cure?

Ketoconazole topical (for the skin) is an antifungal medicine used to treat infections such as athlete’s foot, jock itch, ringworm, and seborrhea (dry, flaking skin or dandruff).

Is ketoconazole good for hair growth?

While ketoconazole is most frequently used for its antifungal properties to treat infections or conditions like seborrheic dermatitis, there is anecdotal evidence indicating that it may also help promote hair growth or reduce hair loss.

How safe is ketoconazole?

Ketoconazole can cause serious harm to your liver that may result in liver transplant or cause death. Call your doctor at once if you have any signs of liver damage, such as nausea, vomiting, stomach pain, fever, tiredness, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

Is anastrozole a form of chemo?

Anastrozole (Arimidex┬«) is a Chemotherapy Regimen for Breast Cancer – early stage.

Should I take anastrozole at night?

Anastrozole is taken once a day in tablet form. The pills are taken at the same time each day, either in the morning or at night. Always take the pills exactly as your nurse or pharmacist has told you. This is important to ensure that it is working as well as possible.

Does anastrozole affect your immune system?

Taking hormone therapy does not affect your immune system. Hormone therapies, including tamoxifen, letrozole, anastrozole, exemestane and goserelin, do not affect your risk of getting coronavirus or of becoming seriously ill if you do get it.

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