What is amikacin used to treat?

Amikacin injection is used to treat certain serious infections that are caused by bacteria such as meningitis (infection of the membranes that surround the brain and spinal cord) and infections of the blood, abdomen (stomach area), lungs, skin, bones, joints, and urinary tract.

How is amikacin given?

Amikacin sulphate injection may be given intramuscularly or intravenously. Amikacin should not be physically premixed with other drugs, but should be administered separately according to the recommended dose and route. The patient’s pre-treatment bodyweight should be obtained for calculation of correct dosage.

What is another name for amikacin?


Clinical data
Trade names Amikin, Amiglyde-V, Arikayce, others
AHFS/Drugs.com Monograph
MedlinePlus a682661
License data US DailyMed: Amikacin

What is the major side effect of amikacin?

Common side effects of Amikacin Sulfate Injection include:

  • diarrhea,
  • hearing loss,
  • spinning sensation (vertigo),
  • numbness,
  • skin tingling,
  • muscle twitching and convulsions,
  • dizziness,
  • ringing or roaring in the ears,

Is amikacin used for UTI?

Amikacin is a highly effective aminoglycoside, highly effective against extended spectrum beta lactamase (ESBL) bacteria. Older patients suffer from more urinary tract infection (UTIs), and have a higher frequency of infection with resistant bacteria, mainly among frail nursing home residents.

Why amikacin is given once daily?

Once-daily amikacin demonstrated killing activity over the initial 8 h superior to those of all other drugs administered as monotherapy against both strains tested (P < 0.01). Regrowth by 24 h was greatest for the amikacin regimen (P < 0.01) butwas apparent for all monotherapy regimens against both strains.

Can amikacin damage kidneys?

Amikacin can harm your kidneys, and may also cause nerve damage or hearing loss, especially if you have kidney disease or use certain other medicines. Tell your doctor about all your medical conditions and all the medicines you are using. If you need surgery, tell the surgeon ahead of time that you are using amikacin.

Is amikacin single use?

Use: Amikacin injection is used to treat susceptible gram-negative bacterial infections. Packaging: Package in sterile, tight, single-use containers. Labeling: For professional use only. Keep out of the reach of children.

Can amikacin be given alone?

Amikacin is rarely used alone and often combined with other antimicrobials.

Which is better amikacin or gentamicin?

Gentamicin was more active than amikacin against most species of enterobacteria, Haemophilus influenzae and Staphylococcus aureus but amikacin was more active against a proportion of Klebsiella and Providencia isolates.

What drugs interact with amikacin?

Most frequently checked interactions

  • Acetylsalicylic Acid (aspirin)
  • Activated Charcoal (charcoal)
  • Adrenalin (epinephrine)
  • Augmentin (amoxicillin / clavulanate)
  • B Complex 100 (multivitamin)
  • Bactrim (sulfamethoxazole / trimethoprim)
  • Calcium 600 D (calcium / vitamin d)
  • Cipro (ciprofloxacin)

Does amikacin cause sleepiness?

Check with your doctor right away if you or your child have blood in the urine, change in frequency of urination or amount of urine, difficulty with breathing, drowsiness, increased thirst, loss of appetite, nausea or vomiting, swelling of feet or lower legs, or weakness.

Does amikacin need to be refrigerated?

Amikacin Sulfate Injection USP is supplied as a clear colorless to light straw colored solution which requires no refrigeration. At times the solution may become a very pale yellow; this does not indicate a decrease in potency.

What is the best antibiotic for a UTI?

Drugs commonly recommended for simple UTIs include:

  • Trimethoprim/sulfamethoxazole (Bactrim, Septra, others)
  • Fosfomycin (Monurol)
  • Nitrofurantoin (Macrodantin, Macrobid)
  • Cephalexin (Keflex)
  • Ceftriaxone.

Is amoxicillin good for urinary tract infection?

UTIs can cause infection and inflammation. Doctors commonly prescribe antibiotics such as amoxicillin to treat urinary tract infections and help you feel better.

Which urine is best for urine culture?

You will need to collect a urine sample. You will need to drink enough fluids and avoid urinating so that you will be able to collect a urine sample. The first urine of the day is best because bacterial levels will be higher. Avoid urinating just before having this test.

Is amikacin broad or narrow spectrum?

Amikacin is a parenterally administered, broad spectrum aminoglycoside antibiotic typically used for severe gram negative infections.

How do you prepare amikacin injection?

The solution for intravenous use is prepared by adding the contents of a 500 mg vial to 100 or 200 mL of sterile diluent such as 0.9% sodium chloride injection or 5% dextrose injection or any of the compatible solutions listed below. The solution is administered to adults over a 30 to 60 minute period.

Can amikacin cause nausea?

Nausea, vomiting, stomach upset, or loss of appetite may occur. Pain/irritation/redness at the injection site may infrequently occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Is amikacin renal toxic?

Amikacin is a commonly used antibacterial drug that can cause significant nephrotoxic effects in both humans and experimental animals. It has been reported that one mechanism of the toxic effects of aminoglycoside antibiotics are the result of oxidative reactions.

Is amikacin available in pill form?

Drug – Alnamik (500mg) 100mg – 1 Tablets Tablet (Amikacin) Price List or Cost of Medication | Medindia.

Does amikacin cause diarrhea?

What drugs and food should I avoid while taking Amikacin (Amikin)? Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

What are two serious side effects of gentamicin and tobramycin?

Let your child’s doctor or nurse know as soon as possible if your child has any of these side effects:

  • loss of hearing.
  • ringing or buzzing in the ears.
  • feeling of fullness of the ears.
  • increased thirst.
  • needing to urinate more or less frequently than usual.
  • skin rash or itchiness.
  • unusual drowsiness, dizziness, or weakness.

What is time dependent killing?

Time-Dependent Killing: For certain classes of antibiotics, the major killing effect against an organism is produced by either the time or the concentration of the drug at the binding site.

What is a major side effect of aminoglycosides?

The major side effects of aminoglycosides are kidney injury, hearing impairment and vestibular toxicity.

Is amikacin safe in renal failure?

Conclusion: Amikacin usage in described, lowered doses with prolonged interval between them is safe in terms of ototoxicity and nephrotoxicity in patients with chronic kidney disease. Every two days dosage is less effective than every day dosage in patients with stage 4 CKD.

Can amikacin cause hearing loss?

Adverse drug reactions are an important consideration for patients treated for MDR-TB infection where the prolonged treatment with amikacin or kanamycin is likely to result in the development of permanent hearing loss [16].

Is amikacin safe for babies?

Treatment of infants with amikacin give 15 mg/kg intravenously or intramuscularly to infants this. Give a dose every 36 hours in infants less than 28 weeks gestation in the first week of life. Give all other infants a dose once-daily unless renal function is poor.

Is amikacin safe in elderly?

Amikacin alone or in combination can be regarded as an efficacious and safe antibiotic in the treatment of severe gram-negative infections in elderly patients, whether the daily dose is administered in a single infusion or in a BID interval.

What are tetracycline antibiotics used to treat?

Tetracycline is used to treat infections caused by bacteria including pneumonia and other respiratory tract infections; ; certain infections of skin, eye, lymphatic, intestinal, genital and urinary systems; and certain other infections that are spread by ticks, lice, mites, and infected animals.

What are aminoglycoside antibiotics used for?

Aminoglycosides are used in the treatment of severe infections of the abdomen and urinary tract, as well as bacteremia and endocarditis. They are also used for prophylaxis, especially against endocarditis.

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